Ergothioneine Improves Memory & Sleep in Older Adults

Cognitive decline is common in older people. A still little discussed nutrient found

in mushrooms, ergothioneine, might help.

Ergothioneine is a vitamin-like amino acid found most abundantly in mushrooms.

Evidence is mounting that, because of its antioxidant, inflammation regulating

and detoxifying properties, ergothioneine may powerfully promote longevity.

Studies show that ergothioneine levels are lower in elderly people with mild

cognitive impairment.

North Americans may not get enough ergothioneine in their diet. When

Americans add mushrooms to their diet, rates of premature death go down by

16%: 35% if you also reduce red meat.

You can increase ergothioneine by eating more mushrooms, especially shiitake,

maitake, lion’s mane and oyster. You can also increase ergothioneine with

supplements.

Several studies have shown that low levels of ergothioneine are associated with

mild cognitive impairment, dementia, cerebral vascular disease and Parkinson’s.

One study found that low levels of ergothioneine predict quicker cognitive

decline. But few studies have looked at the effect of supplementing ergothioneine

on cognition.

This new 16-week, double-blind, placebo-controlled study included 127 people

between 55 and 79 years old with subjective memory complaints but no mild

cognitive impairment or dementia.

It found that 25mg of ergothioneine significantly protected against subjective

memory decline compared to placebo. This result is important both in itself and

because subjective memory assessment is increasingly being recognized as an

important marker of early cognitive decline and later dementia.

The study also found that 25mg of ergothioneine significantly improved ease of

falling asleep compared to the placebo group. This important study provides preliminary promise for ergothioneine as a longevity nutrient that could improve memory.

Nutraceuticals. 2025;5(3):15.

Our supplements department contains a variety of mushroom supplements, that can contain naturally occurring ergothioneine.